As COVID-19 begins to spread to the most fragile regions of the world, humanitarian organizations are facing pre-existing hurdles—often diffuse and indirect—hindering the deployment of an appropriate and timely response to the virus in countries under sanctions. Sanctioned jurisdictions represent around 75% of the beneficiary states of the United Nations (UN) Global Humanitarian Response Plan to COVID-19. With urgency growing by the day, what can the UN system, particularly the UN Security Council, do to ensure that humanitarian organizations can fulfill their mission during the pandemic, in its immediate aftermath, and in the long-term?