The measures used to prevent and control the spread of COVID-19 have led to disruptions to families, friendships, daily routines and wider community dynamics. These have had many harmful consequences for children’s protection, well-being, and development. As countries move past confinement and quarantine measures, the socio-economic and political impact of these measures will continue. Reduced economic opportunities, loss of employment and income, disrupted societal and community level trust and cohesion, food insecurity, and other impacts including psychosocial distress will continue putting children’s well-being and healthy development at risk. Aim of this brief: To support child protection practitioners and policy makers in putting the child’s safety and well-being at the centre of their COVID-19 pandemic response.