Africa has responded swiftly to the COVID-19 pandemic and, as of now, reported cases are lower than early pessimistic estimates. It is too early to know the full impact of COVID-19 on Africa. To date, the experience has been varied. Moreover, as with other regions, there is not one homogenous narrative around the COVID-19 pandemic in Africa. The pandemic is affecting African countries differently, given varied strengths and vulnerabilities. There are causes for concern, but also reasons for hope. Much hangs in the balance. Vigilance and preparedness are critical.