World Vision International and Search for Common Ground voice serious concerns about the immediate and long-term impact of COVID-19 and ongoing response measures on the well-being of people, in particular of children and young people, living in conflict-affected and fragile contexts. In this brief, they aim to highlight the need for a conflict-sensitive response and provide recommendations for strengthening European donors’ global COVID-19 response. As leading donors and in line with commitments to integrated responses to crises and fragility, including the European Union’s (EU) Integrated Approach, the EU and European government’s public health responses to COVID-19 in conflict-affected contexts must give local conflict dynamics due attention. Responses that do not consider the socio-political and human security context will likely fail and can worsen conflict-dynamics, as we have learned from our interventions in West Africa and the Democratic Republic of Congo to fight Ebola. Conflict-sensitivity is essential to reduce risks of attacks on treatment centres, resistance to health instructions, and new social tensions in the communities we serve. From a conflict sensitivity perspective, they have three concerns about COVID-19 interventions in conflict-affected contexts.