COVID-19 as a truly global pandemic presents a unique opportunity to reflect – through an ‘anti-colonial’ lens – on the role that WHO plays in low- and middle-income countries (LMICs) versus high-income countries (HICs). This divide, also referred to as the global south and the global north, coincides in many ways with the separation between former colonies and colonial powers. This commentary will use COVID-19 as a case study to argue that the WHO can contribute to the redistribution of power from the global north to south through the horizontal exchange of knowledge and the incorporation of best practice examples from the global south.