The novel coronavirus (COVID-19) was first reported in the Horn of Africa region in early March 2020. At first, the number of cases seemed low compared to other regions, both on the continent and around the globe; however, these figures did increase steadily. Six months into the pandemic, it is encouraging to note the downward trend in the number of cases and deaths over the past few weeks. Thus far, more than 150,000 cases have been reported in the Horn of Africa; however, testing capacity is still quite limited, making the numbers a poor indicator of the actual infection rate. As pointed out by Africa Centres for Disease Control and Prevention (Africa CDC), both the drastic preventative measures applied across Africa by governments in the first months of the pandemic and the continent’s young population certainly played a significant role in limiting the devastating impact of the virus, as seen elsewhere. Regional and international efforts have also helped in hampering the immediate impact of the pandemic, but a sustained and coordinated effort is needed to reduce the longer-term effects of COVID-19, particularly the effects on public health and the economy.