The paper will provide an examination and highlights on Government Response to the Corona Virus (COVID-19) Crisis. Critical examination will be on registered success, failure and lesson learned for future management of public health crises in South Sudan. The paper also looks at the gender responses and approaches in managing the virus and finally offers some lessons learned and strategic policy recommendations that help the government to better handle and manage the future of this health crisis in South Sudan. The policy paper is developed based on existing secondary data sources, and informal interactions, interviews and consultations with a wide variety of stakeholders including CSOs, general public health workers and government officials.