In partnership with UNDP- PaCC Project, the University of Juba Technical Multi-Disciplinary Sub-Committee on COVID-19 pandemic response conducted a rapid assessment to determine the gender and socio-economic impact of the disease on South Sudanese. The novel COVID-19 pandemic has infected over three million people, with over two hundred thousand deaths globally. With a weak and fragile health system, the emergence of COVID-19 pandemic is likely going to inflict heavy social-economics and human pain.