Gender is shaping the COVID-19 crisis in real and significant ways. Beyond the direct, visible practices that by now we all should understand—stay home, wash your hands, step back six feet—gender and its interactions with class, race, and immigrant status impact a number of dimensions of this crisis. From epidemiology to the vulnerabilities of front-line health workers, from the distribution of care work within families to the implications of quarantine for domestic violence, the author argues that we need to reflect critically on these interactions to shape a truly effective policy response to this pandemic.